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The agency responsible for inspecting compliance with federal and state safety requirements for commercial motor vehicles is the Federal Motor Carrier Safety Administration (FMCSA). This federal agency specifically focuses on regulating the trucking industry in the United States and ensuring that commercial motor vehicles meet safety standards. The FMCSA establishes regulations that govern the operation of commercial vehicles, conducts inspections, and enforces safety compliance.
While the Department of Transportation and the State Patrol play significant roles in roadway safety and law enforcement, their focus is broader and not exclusively on commercial vehicle inspections. Local police departments also have a role in traffic enforcement, but they generally do not specialize in the specific inspections related to commercial motor vehicles that are within the jurisdiction of the FMCSA. Thus, the correct answer reflects the specialized function of the FMCSA in ensuring the safety and compliance of commercial motor vehicles on the nation's roads.